https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29324 Wed 11 Apr 2018 11:07:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51997 Tue 26 Sep 2023 11:07:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33471 -/- mice compared to Cd151^+/+ controls. This study identified 72 up-regulated and 183 down-regulated genes in FVB/N Cd151^-/- compared to Cd151^+/+ glomeruli (p<0.05). Further analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matrix protein mindin (encoded by Spon2) in the diseased FVB/N Cd151^-/- GBM that did not occur in the C57BL/6 diseased-resistant strain. Interestingly, mindin was also detected in urinary samples of FVB/N Cd151^-/- mice, underlining its potential value as a biomarker for glomerular diseases associated with GBM alterations. Gene set enrichment and pathway analysis of the microarray dataset showed enrichment in axon guidance and actin cytoskeleton signalling pathways as well as activation of inflammatory pathways. Given the known function of mindin, its early expression in the diseased GBM could represent a trigger of both further podocyte cytoskeletal changes and inflammation, thereby playing a key role in the mechanisms of disease progression.]]> Tue 03 Sep 2019 18:26:44 AEST ]]>